The Organic Chemistry of Drug Design and Drug Action

The Organic Chemistry of Drug Design and Drug Action

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Key Features
  • Format: Hardback
  • Number of Pages: 536 pages
  • Dimensions: 224 x 278 x 30mm
  • Weight: 1,719.97g
  • Publication date: 26 Jun 2014
  • Publisher: Elsevier Science Publishing Co Inc
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The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows the reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition reflects significant changes in the process of drug design over the last decade. It preserves the successful approach of the previous editions while including significant changes in format and coverage. New to this edition: * Updates to all chapters, including new examples and references* Chapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the book* Chapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistry* Chapter 3 (Receptors): Drug-receptor interactions, cation-? and halogen bonding; atropisomers; case history of the insomnia drug suvorexant* Chapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesis* Chapter 5 (Enzyme Inhibition and Inactivation): New case histories: * for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinib* for transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazid* for slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptin* Chapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examples* Chapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolites* Chapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody-drug conjugates

Key Features
  • Format: Hardback
  • Number of Pages: 536 pages
  • Dimensions: 224 x 278 x 30mm
  • Weight: 1,719.97g
  • Publication date: 26 Jun 2014
  • Publisher: Elsevier Science Publishing Co Inc
  • Imprinte: Academic Press Inc
  • Publication City/Country: San Diego, United States
  • Language: English
  • Edition: Revised
  • Edition statement: 3rd Revised edition
  • Illustrations note: black and white tables, figures
  • ISBN10: 0123820308
  • ISBN13: 9780123820303
Specifications of The Organic Chemistry of Drug Design and Drug Action
SKU
JU030BKAJ6L1NAFAMZ
Model
9780123820303
Author
Richard Silverman, Mark W Holladay
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